AbbVie Senior Scientist, Antibody Drug Conjugates in Worcester, Massachusetts

Senior Scientist, Antibody Drug Conjugates


USA, Massachusetts, Worcester at

Research & Development at

1800967Requisition #

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Company Overview:

AbbVie (NYSE: ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 26,000 people worldwide and markets medicines in more than 170 countries.

The Role:

AbbVie has an opening for a Senior Scientist in Discovery to conduct pre-clinical research and development in the are of antibody drug conjugates (ADCs).

Key Responsibilities Include:

  1. Synthesis, purification and characterization of ADCs on mg to gram scale.

  2. Development and optimization of conjugation protocols utilizing novel chemistries and technologies.

  3. Development and optimization of automated techniques for ADC synthesis and purification.

  4. Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie.

  5. Protein Purification experience required


Grade level will be based on education & years of experience

Educational Requirements:

PhD in Organic Chemistry, Biochemistry, Chemical Biology or other relevant discipline with 0-3+ years of relevant experience.


  • Hands-on experience with generation and characterization of antibody drug conjugates preferably in the area of biotherapeutics.

  • Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).

  • Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.

  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented and able to work in a fast-paced team environment with demonstrated problem solving skills.

  • High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.

Key Leadership Competencies:

  1. Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.

  2. Learns fast, grasps the "essence" and can change course quickly where indicated.

  3. Raises the bar and is never satisfied with the status quo.

  4. Creates a learning environment, open to suggestions and experimentation for improvement.

  5. Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled